Boydbolt, a positive-latch, simple-release fastener

Fastener /Boydbolt/ has recently been designed to furnish positive lock and release characteristics that positively prevent accidental adverse functions of lock or release

Polygamy and child mortality: Historical and modern evidence from Nigeria’s Igbo

We use historical and modern data on the Igbo ethnic group in Nigeria to assess the relationship between polygamy and child mortality. We examine several possible channels for this correlation, and test its sensitivity to observable characteristics of individuals, households, and regions in order to infer the scope for selection on unobservables to drive the polygamy-child mortality correlation. We find a statistically significant positive relationship between polygamy and child mortality in the modern period, and a statistically insignificant positive relationship in the historical data. Although there is a limited role for polygamist-specific intra-household dynamics and behavioral practices in shaping the mortality of children in such households, the sensitivity of the polygamy-child mortality correlation is consistent with an important role for selection into polygamy, particularly on unobservable characteristics

The Inclusion of In-Plane Stresses in Delamination Criteria

A study of delamination is performed including strength of materials and fracture mechanics approaches with emphasis placed on methods of delamination prediction. Evidence is presented which supports the inclusion of the in-plane stresses in addition to the inter-laminar stress terms in delamination criteria. The delamination can be modeled as a resin rich region in between ply sets. The entire six component stress state in this resin layer is calculated through a finite element analysis and inputted into a new Modified Von Mises Delamination Criterion. This criterion builds onto previous criteria by including all six stress components. The MVMDC shows improved correlation to experimental data

Allogeneic hematopoietic cell transplantation as curative therapy for patients with non-Hodgkin lymphoma: Increasingly successful application to older patients

AbstractNon-Hodgkin lymphoma (NHL) constitutes a collection of lymphoproliferative disorders with widely varying biological, histological, and clinical features. For the B cell NHLs, great progress has been made due to the addition of monoclonal antibodies and, more recently, other novel agents including B cell receptor signaling inhibitors, immunomodulatory agents, and proteasome inhibitors. Autologous hematopoietic cell transplantation (auto-HCT) offers the promise of cure or prolonged remission in some NHL patients. For some patients, however, auto-HCT may never be a viable option, whereas in others, the disease may progress despite auto-HCT. In those settings, allogeneic HCT (allo-HCT) offers the potential for cure. Over the past 10 to 15 years, considerable progress has been made in the implementation of allo-HCT, such that this approach now is a highly effective therapy for patients up to (and even beyond) age 75 years. Recent advances in conventional lymphoma therapy, peritransplantation supportive care, patient selection, and donor selection (including the use of alternative hematopoietic cell donors), has allowed broader application of allo-HCT to patients with NHL. As a result, an ever-increasing number of NHL patients over age 60 to 65 years stand to benefit from allo-HCT. In this review, we present data in support of the use of allo-HCT for patients with diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma. These histologies account for a large majority of allo-HCTs performed for patients over age 60 in the United States. Where possible, we highlight available data in older patients. This body of literature strongly supports the concept that allo-HCT should be offered to fit patients well beyond age 65 and, accordingly, that this treatment should be covered by their insurance carriers

Thriving and Mental Health Outcomes Among Transgender and Gender Non-Conforming Youth in Oregon

A growing body of literature associates transgender and gender non-conforming (TGNC) identity with adverse mental and emotional health outcomes. Only a handful of studies have been conducted using population-based samples of adolescents to study mental health outcomes in TGNC youth (e.g., Eisenberg et al., 2017; Perez-Brumer, Day, Russell, & Hatzenbuehler, 2017; Rider, McMorris, Gower, Coleman, & Eisenberg, 2018; Toomey, Syvertsen, & Shramko, 2018) and only one has looked at outcomes that may indicate thriving (Eisenberg et al., 2017). The current study analyzes data from the 2017 Oregon Heathy Teens Survey (OHTS) (N = 26,747), a population-based biannual survey of eighth and eleventh graders. In 2017, the OHTS included three gender variables: youth report their gender identity, gender presentation (rated on a spectrum from very feminine to very masculine), and perception of others’ evaluation of their gender presentation. The current study examined associations between gender identity and four measures of thriving (emotional/mental health and wellbeing, grades, self-efficacy, and the presence of a caring adult at school) and three measures of adverse mental health outcomes (depressive symptoms, suicidal ideation, and suicide attempt). Multiple and logistic regression were used to test two sets of models. The first set of models included only one indicator of gender identity as a predictor of thriving and adverse mental health outcomes. The second set of models included all three indicators of gender identity as well as interactions between them to provide comparison as to how a more nuanced understanding of gender relates to youth outcomes. Results showed that youth who identified with a TGNC gender identity had the most adverse scores for every outcome compared to their female and male peers. In addition, youth who identified with either a female or a male gender identity, but who reported presenting and/or believing others perceived them as presenting in a non-gender-conforming way (i.e., something other than feminine for females or something other than masculine for males) often reported more adverse outcomes than their fully gender-conforming peers. Finally, outcomes for youth who identified with a TGNC gender identity varied depending on the category of self-presentation or others’ perception that the youth reported. Those outcomes often mirrored results for the gender-conforming gender identity of the category of self-presentation or others’ perception endorsed by the youth (e.g., a TGNC youth who presents as feminine and believes others perceive them as feminine reports lower emotional and mental wellbeing than a TGNC youth who presents as masculine and believes other perceive them as masculine). On this survey, 5.48% of youth claimed a TGNC gender identity, an unprecedented rate for population-based surveys. In addition, only 57.52% of females and 56.04% of males chose the fully gender-conforming options on the self-presentation and others’ perception questions (i.e. feminine for females and masculine for males), a notable outcome given the connection between any degree of gender non-conformity and the lower levels of thriving and higher levels of mental health risk found in this study. Implications include the need for greater support of youth who identify as TGNC, as well as the need for researchers and service providers to not only ask about gender identity beyond the traditional female/male binary, but also to include items on surveys and forms that assess more than one dimension of gender